Why is injectable NAD+ different from oral NMN or NR supplements?

Oral NMN and NR are NAD+ precursors that are converted to NAD+ intracellularly. Injectable NAD+ delivers the coenzyme directly into the bloodstream, achieving high plasma concentrations rapidly. Some research suggests that cells can take up extracellular NAD+ through CD38 and CD73 ectonucleotidases, but the primary benefit of injectable NAD+ may be precursor availability after extracellular hydrolysis to NMN.

What are the main sirtuin targets of NAD+?

SIRT1 regulates autophagy, inflammation, and circadian rhythms. SIRT3 is the primary mitochondrial sirtuin controlling oxidative stress and fatty acid oxidation. SIRT6 is involved in DNA repair and telomere maintenance. All require NAD+ as a substrate, and the NAD+/NADH ratio directly influences their activity level.

Popular

NAD+

Name: NAD+
Price: 35 USD
Availability: InStock

Nicotinamide adenine dinucleotide coenzyme found in every living cell. Substrate for sirtuins and PARP enzymes; declines with age. Studied for metabolic

Anti-AgingRecoveryEnergy

● In Stock

Select Variant

Quantity (vials)

Buy more, save more

—

1+ vials

−5%

3+ vials

−10%

5+ vials

−20%

10+ vials

Total Price

$35

For research & laboratory use only. Not for human consumption.

Half-Life

Short (intracellular conversion from NMN/NR precursors)

Administration Route

IV infusion or subcutaneous injection

Sirtuin Activation

Fuels SIRT1/3/5 for epigenetic repair and metabolic health

Hallmark of Aging

NAD+ declines 50% between age 40-60; restoration is anti-aging

PARP DNA Repair

Essential cofactor for poly(ADP-ribose) polymerase DNA repair

Effect Profile

Based on primary research mechanisms

Cellular Longevity

Collagen Synthesis

Oxidative Protection

Energy Restoration

Effect Timeline

Start

Energy levels increase; mental clarity improves

Week 2

Physical endurance increases; muscle recovery faster

Week 4

Sirtuin activation markers up; oxidative stress decreasing

Week 8

Sustained energy; DNA repair pathway activity elevated

Start — Week 1

Energy levels increase; mental clarity improves

Week 2

Physical endurance increases; muscle recovery faster

Week 4

Sirtuin activation markers up; oxidative stress decreasing

Week 8

Sustained energy; DNA repair pathway activity elevated

Mechanism of Action

NAD+ is the oxidised form of the coenzyme central to cellular energy metabolism, acting as an electron carrier in the mitochondrial electron transport chain. It is the obligate substrate for sirtuin deacetylases (SIRT1-7) which regulate DNA repair, mitochondrial biogenesis, inflammation, and stress response gene expression. It also fuels PARP enzymes (poly-ADP ribose polymerases) that repair single-strand DNA breaks. NAD+ levels decline 40-60% from young adulthood to old age, impairing these repair and regulatory functions.

Scientific Research

NAD+ metabolism and its roles in cellular processes during ageing

Nature Reviews Molecular Cell Biology (2021)

Intravenous and oral NAD+ supplementation in a mouse model of aging

Cell Metabolism (2015)

Product FAQs

Stacks Well With

Epithalon

Synthetic tetrapeptide (Ala-Glu-Asp-Gly) derived from the pineal gland. Studied for telomerase activation, telomere elongation, and lifespan extension in

GHK-Cu

Naturally occurring copper-binding tripeptide (Gly-His-Lys-Cu2+) present in human plasma. Plasma levels decline 60% between ages 20-60. Studied for collagen

NAD+

Sirtuin Activation

Hallmark of Aging

PARP DNA Repair

Effect Profile

Effect Timeline

Mechanism of Action

Scientific Research

Product FAQs

Stacks Well With

Epithalon

GHK-Cu

Related Products

Epithalon

SS-31 (Elamipretide)

MOTS-c

5-Amino-1MQ

Cart