How does epithalon activate telomerase?

Epithalon is believed to stimulate telomerase gene expression (hTERT) in somatic cells that do not normally express the enzyme at high levels. Research by Khavinson and colleagues showed that the peptide interacts with nucleosome chromatin structures and may act as a transcription modulator, upregulating genes involved in cell renewal and longevity.

What is the typical research cycle length for epithalon?

Published research protocols have used courses of 10-20 daily injections repeated 2-3 times per year. Some researchers use a single annual course of 10-20 days. Continuous daily dosing for extended periods has also been studied in animal models.

Popular

Epithalon

Name: Epithalon
Price: 50 USD
Availability: InStock

Synthetic tetrapeptide (Ala-Glu-Asp-Gly) derived from the pineal gland. Studied for telomerase activation, telomere elongation, and lifespan extension in

Anti-AgingSleep

● In Stock

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Quantity (vials)

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1+ vials

−5%

3+ vials

−10%

5+ vials

−20%

10+ vials

Total Price

$50

For research & laboratory use only. Not for human consumption.

Half-Life

Unknown

Administration Route

Subcutaneous injection

Telomere Extension

Only peptide with RCT evidence of telomere lengthening

Pineal Gland Regulation

Restores melatonin secretion and circadian rhythm

Cancer Suppression

Enhances p53 tumour suppressor activity in aged tissue

Effect Profile

Based on primary research mechanisms

Cellular Longevity

Collagen Synthesis

Oxidative Protection

Energy Restoration

Effect Timeline

Start

Improved sleep depth; melatonin rhythm begins normalising

Week 8

Energy levels improve; circadian rhythm stabilises

Week 16

Telomere lengthening observed in research; antioxidant markers up

Week 24

Sustained anti-aging effects; cellular senescence markers reduced

Start — Week 4

Improved sleep depth; melatonin rhythm begins normalising

Week 8

Energy levels improve; circadian rhythm stabilises

Week 16

Telomere lengthening observed in research; antioxidant markers up

Week 24

Sustained anti-aging effects; cellular senescence markers reduced

Mechanism of Action

Epithalon activates telomerase, the enzyme that elongates telomeric DNA at chromosome ends, thereby counteracting the telomere shortening associated with cellular senescence. It also regulates pineal gland melatonin secretion, modulates hypothalamic-pituitary function, and exerts antioxidant effects by reducing lipid peroxidation. Studies in animal models have shown reductions in age-associated pathology and extended median and maximum lifespan.

Scientific Research

Geroprotective effect of epithalon in elderly subjects (randomized controlled trial)

Neuro Endocrinology Letters (2003)

Effect of Epithalon on biomarkers of aging, life span and spontaneous tumor incidence in female Swiss-derived SHR mice

Biogerontology (2002)

Product FAQs

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