Why is MOTS-c called an exercise mimetic?

Name: MOTS-c
Price: 55 USD
Availability: InStock

Exercise elevates circulating MOTS-c levels, and exogenous MOTS-c administration in rodent studies reproduces several exercise-associated metabolic benefits including improved insulin sensitivity and reduced age-associated physical decline. This suggests MOTS-c mediates some of exercise's systemic metabolic signalling.

MOTS-c

16-amino acid mitochondria-derived peptide that activates AMPK and suppresses the folate cycle. Studied for metabolic regulation, insulin sensitivity, and

Anti-AgingEnergy

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Total Price

$55

For research & laboratory use only. Not for human consumption.

Administration Route

Subcutaneous injection

Mitochondrial Hormone

Mitochondria-encoded peptide that regulates nuclear gene expression

Exercise Mimicry

Activates AMPK pathways similar to aerobic exercise

Insulin Sensitivity

Improves glucose uptake in skeletal muscle and liver

Effect Profile

Based on primary research mechanisms

Cellular Longevity

Collagen Synthesis

Oxidative Protection

Energy Restoration

Mechanism of Action

MOTS-c (Mitochondrial Open Reading Frame of the 12S rRNA Type-c) is encoded in the mitochondrial 12S rRNA sequence. It translocates from mitochondria to the cytoplasm and nucleus in response to metabolic stress. In the cytoplasm, it inhibits the folate cycle (specifically the MTHFD2 enzyme), reducing purine synthesis and activating AMPK via AICAR accumulation. Nuclear MOTS-c binds to ARE (antioxidant response elements) and regulates stress response and metabolic genes. Plasma MOTS-c levels decline with age and are elevated by exercise.

Scientific Research

MOTS-c is an exercise-induced mitochondrial-encoded regulator of age-dependent physical decline and muscle homeostasis

Nature Communications (2020)

A mitochondrial microprotein MOTS-c regulates insulin sensitivity and metabolic homeostasis

Cell Metabolism (2015)

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Stacks Well With

Humanin

Mitochondrially-encoded peptide with neuroprotective and metabolic effects. Circulating levels correlate positively with longevity in centenarian studies

NAD+

Nicotinamide adenine dinucleotide coenzyme found in every living cell. Substrate for sirtuins and PARP enzymes; declines with age. Studied for metabolic