How do humanin levels differ between long-lived individuals and average populations?

Name: Humanin
Price: 529 USD
Availability: InStock

Studies in centenarians and their offspring have found significantly higher circulating humanin concentrations compared to age-matched controls. The correlation suggests that higher humanin production may be a feature of longevity-associated physiology, though causality has not been established in humans.

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Humanin

Mitochondrially-encoded peptide with neuroprotective and metabolic effects. Circulating levels correlate positively with longevity in centenarian studies

Anti-AgingGH BoostCognitiveMuscle

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−5%

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−10%

5+ vials

−20%

10+ vials

Total Price

$530

For research & laboratory use only. Not for human consumption.

Half-Life

Unknown

Administration Route

Subcutaneous injection

Mitochondrial Protection

Binds BAX to prevent mitochondria-triggered apoptosis

Alzheimer's Protection

Inhibits amyloid beta neurotoxicity in hippocampal neurons

Cardiovascular Defence

Reduces atherosclerotic plaque formation in animal models

Effect Profile

Based on primary research mechanisms

Cellular Longevity

Collagen Synthesis

Oxidative Protection

Energy Restoration

Mechanism of Action

Humanin is a 21-amino acid peptide encoded within the 16S rRNA gene of mitochondrial DNA, representing a class of mitochondrial-derived peptides (MDPs). It binds to the humanin receptor complex (CNTFR/WSX-1/gp130 or formyl peptide receptor) and activates JAK2/STAT3 signalling. This activation suppresses neuronal apoptosis induced by Alzheimer-associated insults (amyloid-beta, presenilin mutations), promotes insulin sensitivity via IGF-1 signalling, and reduces oxidative stress. Circulating humanin levels are higher in long-lived individuals and centenarian offspring.

Scientific Research

Humanin levels in blood are associated with age and metabolic traits in humans

Aging (2020)

Mitochondria-derived peptide MOTS-c: a regulator of cellular metabolism and stress response

Cell Metabolism (2015)

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Stacks Well With

MOTS-c

16-amino acid mitochondria-derived peptide that activates AMPK and suppresses the folate cycle. Studied for metabolic regulation, insulin sensitivity, and