How does 5-Amino-1MQ differ from NMN or NR as a NAD+ booster?

Name: 5-Amino-1MQ
Price: 75 USD
Availability: InStock

NMN and NR are NAD+ precursors that increase NAD+ by providing biosynthetic substrate. 5-Amino-1MQ raises NAD+ by blocking its consumption via the NNMT pathway. Additionally, it raises SAM levels, providing a methylation benefit not seen with precursor supplementation. The two approaches are complementary and some researchers use them together.

5-Amino-1MQ

Nicotinamide N-methyltransferase (NNMT) inhibitor. Blocks the primary NAD+ consuming pathway outside mitochondria, raising cellular NAD+ levels and activating

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−5%

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−10%

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−20%

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Total Price

$75

For research & laboratory use only. Not for human consumption.

Administration Route

Subcutaneous injection

NNMT Enzyme Inhibitor

Blocks fat cell programming enzyme to reverse obesity

Adipocyte Reprogramming

Converts white fat to metabolically active brown fat

NAD+ Pathway

Raises NAD+ by inhibiting methylation consumption

Effect Profile

Based on primary research mechanisms

Cellular Longevity

Collagen Synthesis

Oxidative Protection

Energy Restoration

Mechanism of Action

NNMT consumes S-adenosylmethionine (SAM) to methylate nicotinamide, producing 1-methylnicotinamide and reducing cellular SAM and NAD+ availability. 5-Amino-1MQ is a small molecule inhibitor of NNMT, blocking this consumption pathway. By inhibiting NNMT, the compound raises NAD+ and SAM levels simultaneously, activating sirtuins (particularly SIRT1) and supporting methylation reactions. In fat cell models, NNMT inhibition reduces adipocyte differentiation and lipid accumulation.

Scientific Research

NNMT inhibition activates a futile cycle that reduces fat mass and improves insulin sensitivity

Nature Medicine (2013)

Product FAQs

Stacks Well With

NAD+

Nicotinamide adenine dinucleotide coenzyme found in every living cell. Substrate for sirtuins and PARP enzymes; declines with age. Studied for metabolic

5-Amino-1MQ

NNMT Enzyme Inhibitor

Adipocyte Reprogramming

NAD+ Pathway

Effect Profile

Mechanism of Action

Scientific Research

Product FAQs

Stacks Well With

NAD+

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