How is Selank different from conventional anxiolytics?

Benzodiazepines work by enhancing GABA-A receptor sensitivity, causing sedation, cognitive impairment, and dependence risk. Selank modulates GABAergic transmission more broadly while also upregulating BDNF, which improves memory consolidation - the opposite of benzodiazepine effects on cognition. It has no known dependence liability and does not cause sedation at research doses.

What does BDNF upregulation by Selank mean for cognition?

Brain-derived neurotrophic factor (BDNF) is essential for long-term potentiation (LTP) - the synaptic strengthening that underlies learning and memory. Selank increases BDNF mRNA and protein expression in the hippocampus and frontal cortex. Higher BDNF levels are associated with improved memory consolidation and are studied as a target for depression and cognitive impairment.

What is the best route of administration for Selank?

Intranasal delivery is the standard clinical route in Russia (approved as a nasal spray). The peptide is absorbed through the olfactory epithelium, providing rapid CNS access. Subcutaneous injection is also studied and may provide more consistent systemic delivery, though CNS penetration rates differ by route.

Popular

Selank

Name: Selank
Price: 60 USD
Availability: InStock

Synthetic heptapeptide anxiolytic developed by the Russian Academy of Sciences. Reduces anxiety without sedation, improves memory consolidation, and

Cognitive

● In Stock

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Quantity (vials)

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1+ vials

−5%

3+ vials

−10%

5+ vials

−20%

10+ vials

Total Price

$60

For research & laboratory use only. Not for human consumption.

Half-Life

~1-2 minutes (intranasal bioavailable form used in clinical practice; active metabolites persist longer)

Administration Route

Intranasal or subcutaneous injection

Anxiolytic Without Sedation

Modulates GABAergic system without drowsiness or dependence

BDNF Upregulation

Increases brain-derived neurotrophic factor for neuroplasticity

Cognitive Enhancement

Improves working memory and attention in stress-exposed models

Effect Profile

Based on primary research mechanisms

Focus & Memory

Neuroprotection

Mood & Anxiety

Neuroplasticity

Effect Timeline

Start

Anxiety reduction noticeable without sedation

Week 2

Improved stress tolerance; sleep quality improves

Week 4

Cognitive performance stable under pressure; mood elevated

Week 8

Sustained anxiolytic effect; BDNF levels elevated

Start — Days 1–5