Name: Melanotan I (Afamelanotide)
Price: 60 USD
Availability: InStock

Question 1

What is the difference between Melanotan I and Melanotan II?

Accepted Answer

Melanotan I (afamelanotide) is a linear peptide that selectively activates MC1R on melanocytes for melanin production without meaningful MC3R/MC4R activation. Melanotan II is a cyclic peptide that activates multiple melanocortin receptors including MC3R/MC4R, producing sexual effects (similar to PT-141), appetite suppression, and tanning simultaneously. MT-I is the approved compound (Scenesse); MT-II has no pharmaceutical approval.

Question 2

What is erythropoietic protoporphyria (EPP) and why is afamelanotide used for it?

Accepted Answer

EPP is a rare inherited disorder of haem biosynthesis where excess protoporphyrin IX accumulates in the skin, causing extreme photosensitivity - even brief sun exposure causes severe burning pain. Afamelanotide (Scenesse) builds up melanin in skin before sun exposure, providing UV-absorbing protection that allows EPP patients to spend more time outdoors. It received FDA approval in 2019 for this indication.

Question 3

Does Melanotan I require UV exposure to work?

Accepted Answer

Unlike self-tanning products that chemically react with skin proteins, Melanotan I works through actual melanogenesis - stimulating melanocytes to produce eumelanin. This process does not require UV light but occurs faster with UV exposure (which independently activates MC1R through a different mechanism). In EPP trials, patients built up melanin protection before UV exposure.

Melanotan I (Afamelanotide)

Controlled Tanning

UV Protection

Longer Half-Life

Effect Profile

Mechanism of Action

Scientific Research

Product FAQs

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Melanotan II

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