Melanotan II

Melanotan II

Cyclic alpha-MSH analogue activating MC1R through MC4R. Produces tanning, sexual effects, and appetite suppression simultaneously. Widely studied for

SkinLibido
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1+ vials
−5%
3+ vials
−10%
5+ vials
−20%
10+ vials

Total Price

$60

For research & laboratory use only. Not for human consumption.

Half-Life

~33 minutes

Administration Route

Subcutaneous injection

Rapid Tanning

Cyclic alpha-MSH analogue produces deep tan in 7-14 days

Libido Enhancement

MC4R activation drives arousal as side effect

Multi-Receptor Action

Binds MC1R (tan) + MC4R (arousal) + MC3R (appetite)

Effect Profile

Skin Tone

0%

Collagen Density

0%

Anti-Wrinkle

0%

Wound Healing

0%

Effect Timeline

Start — Days 3–7

Initial pigmentation change; subtle darkening begins

Week 2

Tan significantly visible; 3–5 UV sessions sufficient

Week 4

Deep tan achieved; maintenance dose reduces UV exposure needed

Week 8

Tan maintained with minimal UV; photoprotective pigment stable

Mechanism of Action

Melanotan II is a cyclic lactam analogue of alpha-MSH (cyclo[Nle4,Asp5,D-Phe7,Lys10]-alpha-MSH(4-10)) that activates MC1R, MC3R, MC4R, and MC5R with high affinity. MC1R activation produces melanogenesis; MC4R activation in the hypothalamus drives sexual motivation (the PT-141 mechanism) and appetite suppression; MC3R modulates energy homeostasis. This pan-melanocortin activity produces the combination of effects observed in research studies.

Scientific Research

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