What is the standard CJC-1295 + ipamorelin protocol?

The combination is typically administered together in the same subcutaneous injection. Both peptides can be drawn into the same syringe after reconstitution. Timing is usually before sleep and/or upon waking in a fasted state for maximum GH response. The synergistic effect comes from simultaneous GHRH receptor activation (CJC-1295) and ghrelin receptor activation (ipamorelin).

Why is CJC-1295 without DAC also called Mod GRF 1-29?

Native GHRH is 44 amino acids. The active fragment is residues 1-29 (GRF 1-29 or Sermorelin). CJC-1295 without DAC modifies this fragment with four amino acid substitutions at positions 2, 8, 15, and 27 to resist enzymatic degradation - hence Modified GRF 1-29. The four substitutions increase stability from ~7 minutes (native GRF 1-29) to ~30 minutes.

Can CJC-1295 without DAC be used alone without ipamorelin?

It can, but the effect is significantly weaker. CJC-1295 without DAC amplifies GH release, but without a GHRP co-stimulation, the GH pulse is modest. The ipamorelin combination produces synergistic effects that are 3-5x greater than CJC-1295 alone.

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CJC-1295 without DAC

Name: CJC-1295 without DAC
Price: 60 USD
Availability: InStock

Modified GHRH fragment (Mod GRF 1-29) that produces acute, physiological GH pulses when combined with a GHRP. The standard pairing with ipamorelin for clean GH

GH BoostHormonal

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−5%

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−10%

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−20%

10+ vials

Total Price

$60

For research & laboratory use only. Not for human consumption.

Half-Life

~30 minutes

Administration Route

Subcutaneous injection

Physiological GH Pulse

Short-acting GHRH analogue mimics natural pulsatile release

No Receptor Desensitisation

Preserves GHRH receptor sensitivity vs DAC version

Flexible Dosing

Multiple daily doses match natural GH rhythms

Effect Profile

Based on primary research mechanisms

Muscle Growth

Fat Oxidation

Recovery Speed

Strength

Mechanism of Action

CJC-1295 without DAC (Mod GRF 1-29) is a modified version of GHRH(1-29) with four amino acid substitutions that prevent enzymatic cleavage without adding albumin-binding chemistry. It binds pituitary GHRH receptors and activates adenylyl cyclase via Gs protein coupling, amplifying GH synthesis. Without DAC, it is cleared within 30 minutes, producing discrete GH pulses rather than sustained elevation.