Cagrisema

Cagrisema

Pre-formulated combination of cagrilintide (amylin analog) and semaglutide (GLP-1 agonist). Phase 2 data showed 15.6% weight reduction with a favourable

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Total Price

$95

For research & laboratory use only. Not for human consumption.

Half-Life

7 days (both components)

Administration Route

Subcutaneous injection

Dual Hormone Mimicry

Combines amylin (cagrilintide) + GLP-1 (semaglutide) action

15.6% Weight Loss

Phase 2 SCALE trial at 32 weeks, exceeds monotherapy

Reduced Side Effects

Amylin component buffers GLP-1 GI effects

Effect Profile

Fat Loss

0%

Hunger Control

0%

Metabolic Health

0%

Energy

0%

Mechanism of Action

CagriSema combines cagrilintide (amylin receptor agonist) and semaglutide (GLP-1 receptor agonist) in a single formulation. The two compounds act through distinct receptor systems: semaglutide reduces appetite and slows gastric emptying via hypothalamic and brainstem GLP-1 receptors, while cagrilintide acts on brainstem amylin receptors to independently promote satiety and suppress post-prandial glucagon. The combination of complementary pathways produces additive weight reduction greater than either agent alone.

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